Pompey will look to maintain their recent good form when they welcome high-flying Rotherham to the south coast on Tuesday night.
And Kenny Jackett’s side are the 21/20 favourites with Sky Bet to secure all three points at Fratton Park.
The visitors – who fought from two-goals down to win at MK Dons on Saturday – can be backed at 23/10, with the draw also at 23/10.
Pompey were beaten 1-0 in each of the sides’ past two meetings and there are odds of 7/1 on them gaining revenge by that scoreline.
More optimistic punters might instead prefer to put their money on a 2-1 win 8/1 or even a 3-0 success at 18/1.
If you are expecting a trickier evening for the hosts, then take a look at them coming from behind to emerge victorious at 11/1.
Alternatively, if you reckon they will be leading at both the interval and full-time then that is on offer at 9/4.
And you can also take advantage of a Sky Bet boost, with the Blues coming out on top in a contest where both sides find the target moving from 3/1 to 7/2.
Leading marksman Ellis Harrison is the joint 9/2 favourite to net the opener, along with fellow forwards John Marquis and Brett Pitman.
Elsewhere in the first goalscorer market, Ronan Curtis, Ryan Williams and Lee Brown are available at 13/2, 9/1 and 66/1 respectively.
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Please note that in-stadia betting is no longer available at Fratton Park.