You have to go back to the 2011/12 campaign to find the last time that Pompey met their south coast rivals.
Both games during that Championship campaign finished all squad – although it was certainly the Blues fans who felt more like celebrating following the final whistle.
Joel Ward and David Norris both wrote their names in Fratton folklore by grabbing dramatic equalisers.
The latter’s is certainly the most memorable, with a superb volley deep into stoppage-time at a stunned St Mary’s.
But Southampton secured promotion at the end of that season and have remained in the Premier League since, despite a couple of recent flirtations with the drop.
And Pompey – who were then deep in financial crisis – were relegated, still trying to negotiate their way back up the divisions.
Both teams enter the game on the back of league setbacks, with Ralph Hasenhüttl’s men beaten by neighbours Bournemouth on Friday night.
It leaves them 13th in the top-flight table and that clash with the Cherries was labelled a derby by some.
Supporters of a Pompey or Southampton persuasion, however, know that this is the only true south coast derby.
Tom Naylor will require a fitness test after collecting a knock at Wycombe, while Ellis Harrison’s red card sees him serve a one-match ban.
Pompey are also without the injured quartet of Lee Brown (Achilles), Marcus Harness (thigh), Bryn Morris (groin) and Jack Whatmough (knee).
Moussa Djenepo is missing for the visitors with a muscle injury in his leg, while there are doubts over the fitness of Nathan Redmond (ankle).
HEAD TO HEAD*
Pompey: 9 wins
Southampton: 19 wins
At Fratton Park
Pompey: 4 wins
Southampton: 8 wins
*Football League/FA Cup/League Cup matches only
There are no seats available for this game, so please do not travel to the ground if you do not have a ticket.
Turnstiles are open from 6.15pm this evening, while fans will be able to use the Victory Bar from 4.30pm.
Please note that the car park is full for this game and there are no more spaces available.
For a full list of ticketing and access information for tonight’s match, please click on the link to the left.
Referee: Kevin Friend
Assistants: Matthew Wilkes, Mark Scholes
Fourth Official: Dean Whitestone
iFollow subscribers and audio match pass holders can listen to live commentary from Chris Wise and Guy Whittingham by signing into their account and visiting the match centre from 7pm this evening.
Please note that Carabao Cup matches are not available to watch live on iFollow, either by overseas or domestic supporters.
Viewers in the UK can watch the game live on Sky Sports Football, while overseas supporters should check their local listings.
ALSO IN CARABAO CUP
Games kick-off at 7.45pm unless stated
Arsenal v Nottingham Forest
Colchester v Tottenham
Crawley v Stoke
Luton v Leicester
Preston v Manchester City
Sheffield Wednesday v Everton
Watford v Swansea
Brighton v Aston Villa
Burton v Bournemouth
Chelsea v Grimsby
MK Dons v Liverpool
Oxford v West Ham
Sheffield United v Sunderland
Wolves v Reading
Manchester United v Rochdale (8pm)