Pompey will begin the season by facing Shrewsbury for the second year in succession.
Unlike last term, however, Kenny Jackett’s side will get started at Fratton Park on Saturday, September 12.
The first match on the road sees a long trip to Rochdale the following weekend, while August comes to a close with a visit from recently relegated Wigan.
Pompey will bring the 2020/21 campaign to a close on home soil against Accrington on Saturday, May 8.
Fratton Park is the venue for the traditional Boxing Day fixture, with the Blues facing League Two champions Swindon.
They then close 2020 by heading to Bristol Rovers on Tuesday, December 29, while 2021 starts with a mammoth trek to Accrington on Saturday, January 2.
The Easter weekend brings a home clash with Rochdale on Good Friday (April 2) and then an away test at Wigan on the Monday (April 5).
There are 12 evening midweek contests due to the delayed start to the season, with five at Fratton Park and seven on the road.
Sunderland (March 9) and Fleetwood (December 15) will both have to make the long journey down for an evening kick-off.
Meanwhile, there are long Tuesday treks to Blackpool (December 1) and Doncaster (March 2) for the Blues to endure.
The full fixture list is below, but fans can sync them all to their digital calendar, with any changes updated automatically.
Pompey advise fans not to book any travel or accommodation while it is still unclear when (or how many) supporters will be able to attend games.
| Date | Opposition | Kick-Off |
| Sat, Sep 12 | Shrewsbury (H) | 3pm |
| Sat, Sep 19 | Rochdale (A) | 3pm |
| Sat, Sep 26 | Wigan (H) | 3pm |
| Sat, Oct 3 | Burton (A) | 3pm |
| Sat, Oct 10 | MK Dons (H) | 3pm |
| Sat, Oct 17 | Doncaster (H) | 3pm |
| Tue, Oct 20 | Gillingham (A) | 7.45pm |
| Sat, Oct 24 | Sunderland (A) | 3pm |
| Tue, Oct 27 | Northampton (H) | 7.45pm |
| Sat, Oct 31 | Charlton (H) | 3pm |
| Tue, Nov 3 | Lincoln (A) | 7.45pm |
| Sat, Nov 14 | Plymouth (A) | 3pm |
| Sat, Nov 21 | Crewe (H) | 3pm |
| Tue, Nov 24 | Oxford (H) | 7.45pm |
| Tue, Dec 1 | Blackpool (A) | 7.45pm |
| Sat, Dec 5 | Peterborough (H) | 3pm |
| Sat, Dec 12 | Ipswich (A) | 3pm |
| Tue, Dec 15 | Fleetwood (H) | 7.45pm |
| Sat, Dec 19 | Hull (A) | 3pm |
| Sat, Dec 26 | Swindon (H) | 3pm |
| Tue, Dec 29 | Bristol Rovers (A) | 7.45pm |
| Sat, Jan 2 | Accrington (A) | 3pm |
| Sat, Jan 9 | AFC Wimbledon (H) | 3pm |
| Sat, Jan 16 | Fleetwood (A) | 3pm |
| Sat, Jan 23 | Hull (H) | 3pm |
| Tue, Jan 26 | Lincoln (H) | 7.45pm |
| Sat, Jan 30 | Charlton (A) | 3pm |
| Sat, Feb 6 | Plymouth (H) | 3pm |
| Sat, Feb 13 | Crewe (A) | 3pm |
| Sat, Feb 20 | Blackpool (H) | 3pm |
| Tue, Feb 23 | Oxford (A) | 7.45pm |
| Sat, Feb 27 | Gillingham (H) | 3pm |
| Tue, Mar 2 | Doncaster (A) | 7.45pm |
| Sat, Mar 6 | Northampton (A) | 3pm |
| Tue, Mar 9 | Sunderland (H) | 7.45pm |
| Sat, Mar 13 | Peterborough (A) | 3pm |
| Sat, Mar 20 | Ipswich (H) | 3pm |
| Sat, Mar 27 | Shrewsbury (A) | 3pm |
| Fri, Apr 2 | Rochdale (H) | 3pm |
| Mon, Apr 5 | Wigan (A) | 3pm |
| Sat, Apr 10 | Burton (H) | 3pm |
| Sat, Apr 17 | MK Dons (A) | 3pm |
| Tue, Apr 20 | Swindon (A) | 7.45pm |
| Sat, Apr 24 | Bristol Rovers (H) | 3pm |
| Sat, May 1 | AFC Wimbledon (A) | 3pm |
| Sat, May 8 | Accrington (H) | 3pm |
Please note that all dates/times are subject to change