Pompey head back to Fratton Park on Saturday after seeing their long winning run ended at Coventry earlier in the week.
But Kenny Jackett’s side are the 3/5 favourites with Sky Bet to recover from that defeat by beating Shrewsbury.
The visitors – who have not won in the league since before Christmas – can be backed at 19/4, with the draw at 13/5.
More optimistic punters might prefer to put their money on a 2-1 success at 15/2 or even a 4-0 triumph at 25/1.
And you can also take advantage of a Sky Bet boost, with the Blues coming out on top in a contest where both sides hit the target moving from 11/4 to 10/3.
Those expecting a tough afternoon should take a look at Pompey battling from behind to claim the points at 10/1.
Or if you think it will be a more comfortable affair, then they are 11/8 to be leading at both the break and the final whistle.
Leading marksman Ronan Curtis is the 7/2 favourite to net the opener, ahead of strikers Ellis Harrison and John Marquis at 4/1.
Elsewhere in the first goalscorer market, Ryan Williams, Cameron McGeehan and James Bolton are available at 15/2, 9/1 and 28/1 respectively.
Please gamble responsibly and remember that all odds are subject to change. When the fun stops, stop.
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Please note that in-stadia betting is no longer available at Fratton Park.