With so many teams battling it out for League One promotion, Pompey cannot afford to drop many points.
Kenny Jackett’s side slipped outside of the top six with defeat at Fleetwood on Saturday, but will climb back with three points against MK Dons on Tuesday evening.
They will look to maintain their unbeaten league record at Fratton Park, with six of the next seven fixtures – including a cup clash with Arsenal – on home soil.
Meanwhile, the visitors are still looking to confirm their third tier status for next season, but Jackett is not taking any opponents lightly.
The Blues boss said: “Our players will be determined to bounce back because the games come thick and fast and we don’t have time to dwell on things.
“It’s a high standard at the top of the division and I think the Rotherham manager said that you have to win every week just to stand still.
"You can’t always predict which ones are going to be harder and they’re all opportunities for us to collect points."
“We want to keep doing well in our home games, but you also can’t lose ground in those away matches.
“There are some of our promotion rivals to play on the road and matches against lower placed sides here at Fratton Park.
“But you can’t always predict which ones are going to be harder and they’re all opportunities for us to collect points.
“It’s a big seven days for us now and we should enjoy the challenge, while trying to make sure the performances and results are what we’re looking for.”
MK Dons have built up a healthy 13-point cushion to the drop zone and head to Fratton Park unbeaten in five matches.
Jackett said: “They’re a good team and we had quite a lot of the game earlier in the season, but just didn’t get the details right.
“We’ll need to do that and make sure our approach is correct because there are a lot of close matches in this division and the top sides find a way to win them.
“There will certainly be respect for the opposition, but it's more important to make sure we get our team right – on Tuesday and for the rest of the season.”