Pompey will look to take their fine cup form into the league when they host AFC Wimbledon at the weekend.
And Kenny Jackett’s side are the 1/2 favourites with Sky Bet to collect all three points at Fratton Park.
The visitors – who sit just three points above the drop zone – can be backed at 5/1, with the draw at 3/1.
Pompey triumphed 2-1 in last season’s corresponding fixture and a repeat of that scoreline carries odds of 15/2.
More optimistic punters might instead prefer to put their money on a 2-0 victory at 6/1 or even a 4-0 success at 20/1.
Or if you reckon it will be a trickier afternoon, then take a look at the hosts battling from behind to take the points at 10/1.
You can also take advantage of a Sky Bet boost, with both sides finding the target in a contest where the Blues come out on top moving from 9/4 to 11/4.
Leading marksman Ronan Curtis is the 16/5 favourite to net the opener, ahead of strikers Ellis Harrison and John Marquis at 7/2.
Elsewhere in the first goalscorer market, new signings Reeco Hackett-Fairchild, Cameron McGeehan and Steve Seddon are available at 9/2, 7/1 and 18/1 respectively.
Those taking a longer-term view should note that Pompey are the seventh favourites to secure promotion at 3/1.
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Please note that in-stadia betting is no longer available at Fratton Park.