Pompey will look to reach the fifth round of the Emirates FA Cup when they host Barnsley on Saturday.
And Kenny Jackett’s side are the 13/10 favourites with Sky Bet to secure progress on the day at Fratton Park.
The visitors – who are battling to beat the drop from the Championship – can be backed at 19/10, with the draw at 23/10.
It finished goalless when the sides met on the south coast last season and a repeat of that scoreline carries odds of 9/1.
More optimistic punters might prefer to put their money on a 1-0 victory for the hosts at 15/2 or even a 3-0 success at 22/1.
There are several ‘Request A Bet’ specials, including the Blues to get on the scoresheet and win at least four corners at 4/7.
If you are looking for bigger odds, then Pompey coming out on top, both sides hitting the target and the contest containing a minimum of 12 corners and 50 booking points is priced 33/1.
Leading marksman Ronan Curtis is the 4/1 favourite to net the opener, ahead of strikers Ellis Harrison and John Marquis – and former Fratton favourite Conor Chaplin – at 5/1.
Elsewhere in the first goalscorer market, Marcus Harness, Ben Close and Christian Burgess are available at 17/2, 14/1 and 40/1 respectively.
And those who reckon it will be Tom Naylor leading his side up the Wembley steps to lift the cup in May can back that at 100/1.
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Please note that in-stadia betting is no longer available at Fratton Park.