The road to Wembley gets treacherous now that clubs from the Premier League and Championship have entered the FA Cup.
But it is an all League One clash when Pompey visit Fleetwood on Saturday and the hosts are 5/4 favourites to win on the day (or 8/11 to simply reach the next stage).
Kenny Jackett’s side, meanwhile, can be backed at 19/10 (evens to make the fourth round), with the draw at 23/10.
They won 5-2 on their last visit to Highbury Stadium and a repeat of that scoreline carries mighty odds of 200/1.
More realistic punters might, however, prefer to put their money on a 1-0 victory at 9/1 or a 2-1 success at 10/1.
Both sides scored a penalty in that most recent encounter and the Blues being awarded a spot-kick is priced 11/2, while converting one is 15/2.
Those expecting a tricky afternoon should take a look at Pompey recovering from an interval deficit to triumph at 33/1.
Leading marksman Ronan Curtis is the 5/1 favourite to net the opener, ahead of strikers Ellis Harrison and John Marquis at 11/2.
Elsewhere in the first goalscorer market, Brett Pitman, Marcus Harness and Christian Burgess are available at 13/2, 9/1 and 50/1 respectively.
Pompey have made a few trips to Wembley in the 21st century and supporters who reckon they will be lifting the trophy in May can find that priced at 200/1.
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