Pompey switch focus to their defence of the Leasing.com Trophy when they host Scunthorpe on Tuesday evening.
And Kenny Jackett’s side are the 8/15 favourites with Sky Bet to win the quarter-final tie inside 90 minutes.
The visitors – who are sitting 14th in the League Two standings – can be backed at 4/1, with the draw at 11/4.
If you choose the latter option, then you can get odds of 13/2 on either side progressing via a penalty shoot-out.
The Blues triumphed 2-0 when the sides last met at Fratton Park and a repeat of that scoreline is priced 6/1.
Punters might be more tempted by a 1-0 win at 11/2, while the more optimistic can put their money on a 4-0 success at 18/1.
And those expecting a comfortable evening should take a look at Pompey emerging victorious without conceding at 6/4.
Leading marksman Ellis Harrison is 10/3 favourite to net the opener, ahead of strikers Ellis Harrison and John Marquis at 4/1.
Elsewhere in the first goalscorer market, Gareth Evans, Ryan Williams and Brandon Haunstrup are available at 13/2, 15/2 and 40/1 respectively.
With just two League One sides remaining in the competition, Pompey are the 2/1 favourites to lift the trophy at Wembley for a second season in succession.
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