Pompey can climb back into the top six with a positive result against fellow promotion-chasers Sunderland at the weekend.
And Kenny Jackett’s side are the 23/20 favourites with Sky Bet to secure all three points at Fratton Park.
Pompey won 3-1 in last season’s corresponding fixture and a repeat of that scoreline carries odds of 20/1.
The Black Cats finished that contest with just 10 men and either side having a player sent off is available at 3/1.
Those expecting a trickier afternoon can take a look at the hosts recovering from an interval deficit to take the points at 33/1.
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Please note that in-stadia betting is no longer available at Fratton Park.