Pompey can climb back into the top six with a positive result against fellow promotion-chasers Sunderland at the weekend.
And Kenny Jackett’s side are the 23/20 favourites with Sky Bet to secure all three points at Fratton Park.
The visitors – who are also enjoying a fine run of form – can be backed at 23/10, with the draw at 21/10.
Pompey won 3-1 in last season’s corresponding fixture and a repeat of that scoreline carries odds of 20/1.
The Black Cats finished that contest with just 10 men and either side having a player sent off is available at 3/1.
Punters might instead be tempted to put their money on a narrower 1-0 success at 11/2 or even a 4-0 rout at 50/1.
Those expecting a trickier afternoon can take a look at the hosts recovering from an interval deficit to take the points at 33/1.
And you can also take advantage of a Sky Bet boost, with both sides finding the target in a contest where the Blues come out on top moving from 4/1 to 5/1.
Leading marksman Ronan Curtis is the 4/1 favourite to net the opener, ahead of strikers Ellis Harrison and John Marquis at 5/1.
Elsewhere in the first goalscorer market, Ryan Williams, Ben Close and Christian Burgess are on offer at 9/1, 14/1 and 40/1 respectively.
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Please note that in-stadia betting is no longer available at Fratton Park.