Pompey will discover their Leasing.com Trophy semi-final opponents when the draw takes place on Saturday night.
It will be held from 9pm and screened live as part of Quest’s EFL highlights show, with Colin Murray joined by former Barnsley boss Paul Heckingbottom.
Kenny Jackett’s side are looking to win the competition for a second successive season, having defeated Sunderland on penalties at Wembley last term.
They will be joined in the draw by League Two sides Exeter and Salford, while Newport’s quarter-final against Leicester’s under-21s was postponed because of a frozen pitch.
Semi-final ties are scheduled to be played in the week commencing February 17, with both matches screened live on Sky Sports.
Pompey's progress means their home League One match against MK Dons will now be played on Tuesday, February 25.
|Leasing.com Trophy quarter-finals|
|Exeter City 3-0 Stevenage|
|Salford City 2-1 Accrington Stanley|
|POMPEY 2-1 Scunthorpe United|
|Newport County P-P Leicester City U21|