Pompey return to home soil to face Fleetwood in the first of three successive matches taking place at Fratton Park.
And Kenny Jackett’s side are the evens favourites with Sky Bet to boost their promotion hopes by claiming all three points.
The visitors – who are only behind the Blues on goal difference – can be backed at 13/5, with the draw at 11/5.
Pompey were 1-0 winners in last season’s corresponding fixture and a repeat of that scoreline carries odds of 11/2.
More optimistic punters might prefer to put their money on a 2-0 success at 8/1 or even a 4-1 triumph at 50/1.
You can also take advantage of a Sky Bet boost, with the Blues coming out on top in a contest where both sides hit the target moving from 7/2 to 9/2.
And there are several ‘Request A Bet’ specials to cast your eye over, including the game containing more than 3.5 goals and 13 corners at 12/1.
If you think it will be a difficult evening for the hosts, then you can back them to win from behind at 12/1.
Ronan Curtis is the 4/1 favourite to net the opener ahead of strikers Ellis Harrison and John Marquis at 9/2.
Elsewhere in the first goalscorer market, Ryan Williams, Andy Cannon and James Bolton are available at 9/1, 20/1 and 33/1 respectively.
Please gamble responsibly and remember that all odds are subject to change. When the fun stops, stop.
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Please note that in-stadia betting is no longer available at Fratton Park.