Plymouth have the best home record in League One, while Pompey’s form on the road tops the charts.
But something might have to give when the two sides clash at Home Park in front of the Sky Sports cameras this evening (7.45pm kick-off).
Saturday’s results largely went in favour of the Blues, who remain seventh in the standings after 11 games.
Their next opponents are two places – and just as many points – further back, although do have a game in hand.
Ryan Lowe’s men approach the contest on the back of four successive victories in all competitions, including league wins over Doncaster and Swindon on their own patch.
In fact, the only visiting side to leave Devon triumphant this term was Norwich U21s in the EFL Trophy back in September.
Argyle have certainly enjoyed life back in the third tier following their promotion from League Two last term.
They ended up taking the final automatic spot once sides had voted to end the campaign and use the points per game method to determine final placings.
Pompey’s last visit to the Pilgrims came in February 2019, when Ben Close’s opener was cancelled out by Graham Carey in a 1-1 draw.
Pompey have doubts over Tom Naylor and Sean Raggett, who have both been suffering with knocks that left them unable to train.
But there could be returns for Andy Cannon and Jack Whatmough, who are close to recovering from groin and hamstring problems respectively.
Michael Jacobs (knee) and Lee Brown (hamstring) are both definitely missing for the Blues, while Ronan Curtis is away on Republic of Ireland under-21 duty.
Plymouth will be without Luke Jephcott, who is currently with the Wales under-21 side, as well as Lewis Macleod (knee) and Gary Sawyer (ankle).
HEAD TO HEAD
Pompey: 28 wins
Plymouth: 24 wins
At Home Park
Pompey: 10 wins
Plymouth: 14 wins
Referee: Charles Breakspear
Assistants: Ravel Cheosiaua and Mark Derrien
Fourth Official: Alan Young
Supporters in the UK can watch the contest live on Sky Sports Football. If you are based overseas then please check local listings to see if the game is being shown in your region.
Pompey fans can buy their programme for tonigh's game for £2.99 by downloading the 'Matchday Digital' app.
A limited number of printed copies have also been produced. Email email@example.com for more details.
LEAGUE ONE RESULTS
Bristol Rovers 1-4 Fleetwood
Crewe 2-0 Peterborough
Hull 2-0 Burton
Northampton 0-1 Accrington
Shrewsbury 3-3 Swindon
Sunderland 1-2 MK Dons