A sickness bug interrupted Pompey’s plans for Saturday’s FA Cup clash with Harrogate Town.
And after their second round exit at Fratton Park, Danny Cowley hopes to have a couple of key players available again.
George Hirst and Joe Morrell could both make their return to the side when Sheffield Wednesday visit the south coast for a midweek League One contest.
But Cowley revealed that Louis Thompson is set for a spell on the sidelines after suffering a muscle strain in training.
The Blues boss said: “It’s been a challenge and does seem to be one thing after another at the moment.
"The bug has affected a number of the group at different levels, with some of them having their schedule disrupted."
“We’ve had a lot of players unavailable through injury and illness, although I’d rather put my focus into those who are available.
“Joe and George have been back in training on Monday – we’ll have to see whether they’re fit enough to start or be used from the bench.
“The bug has affected a number of the group at different levels, with some of them having their schedule disrupted.
“Louis has strained a muscle at the bottom of the abdominals. We’ll have to wait and see with him, but anticipate he’ll be out for around three-four weeks.
“It’s unfortunate because we had a good run with him. He’s a determined boy, though, and has come through disappointments before, so knows what he needs to do.
“He’s a great professional who works incredibly hard and nobody will be more frustrated than him at the moment.”
🗓 The start of a big week
— Portsmouth FC (@Pompey) December 6, 2021
🔵 Next up at Fratton Park#Pompey