Pompey got back on track by beating Oxford on Tuesday and will now be looking to inflict the same fate on Gillingham this weekend.
Kenny Jackett’s side remain fourth in the League One standings and are six points behind Lincoln in second, while five clear of seventh-placed Accrington.
Their visitors, meanwhile, are 15th and out of the play-off race according to their manager Steve Evans.
He made that declaration following a narrow defeat at struggling AFC Wimbledon earlier in the week.
With 16 matches remaining for the Gills, however, their fans might not have given up hope of a late charge up the table.
The Kent outfit are currently in their eighth successive campaign in the third tier after claiming the League Two title in 2013.
They have only ever won twice at Fratton Park, although both of those successes have come in the past three years.
It was Pompey who came out on top when the sides met at Priestfield back in October, courtesy of goals from John Marquis and Michael Jacobs.
Alex Bass (leg) and Michael Jacobs (hamstring) have both returned to light training, with James Bolton (ankle) still missing.
Gillingham loan midfielder Callum Slattery is set for a spell on the sidelines after injuring his ankle ligaments, while Dominic Samuel (knee) is the only other absentee.
HEAD TO HEAD
Pompey: 20 wins
Gillingham: 9 wins
At Fratton Park
Pompey: 12 wins
Gillingham: 2 wins
Referee: Tim Robinson
Assistants: Nigel Lugg and Andrew Fox
Fourth Official: Rob Smith
Supporters in the UK can watch the action live – with graphics, commentary and replays – by purchasing a match pass for £10.
Please note that subscribers based in the UK and Ireland will still need to purchase a match pass in order to watch the game live.
There will be post-match reaction on the website and our official YouTube channel, with highlights to follow on Sunday.
ALSO IN LEAGUE ONE
All games kick-off at 3pm
AFC Wimbledon v Hull
Bristol Rovers v Shrewsbury
Charlton v Blackpool
Crewe v Sunderland
Fleetwood v Accrington
Ipswich v Doncaster
MK Dons v Oxford
Peterborough v Wigan
Plymouth v Lincoln
Rochdale v Burton
Swindon v Northampton