Pompey have had an unwelcome break of two weeks between matches following a Covid-19 outbreak in the squad.
The gap might be extended even further, with Accrington holding a pitch inspection on Friday afternoon due to low temperatures in Lancashire.
Kenny Jackett believes the decision to postpone games against Swindon and Bristol Rovers over the festive period was correct.
But the entire squad have since returned to action and are ready to make the trip to the Crown Ground if required.
The Blues boss said: “We had to close the training ground down – which was the right thing to do to provide a circuit break and make sure it didn’t spread around.
“We’re clearly not exempt from Covid in football and I used the few days off to take a look at players for next month, as well as the sides we’ve got coming up.
“But we started training again on Monday and have had a normal week of training in the build-up to facing Accrington.
"Everyone was back by Tuesday, which was good for us. We’re pleased to say we’ve got nobody struggling with symptoms – long may that continue."
“One or two players needed an extra day in terms of their quarantine period because you have to apply the letter of the law.
“Everyone was back by Tuesday, which was good for us. We’re pleased to say we’ve got nobody struggling with symptoms – long may that continue.
“It gives us the best chance of being fit and prepared, making sure that we don’t lose any of our rhythm.”
Accrington are currently sitting eighth in the League One standings, but have up to three games in hand on the sides above them.
Jackett said: “They’ve had a really good run and have recruited well, with a nicely balanced team – it’s never an easy place to go.
“Accrington are in the top half of the table and one of a number of sides looking at those promotion and play-off places.
“They’ve settled on a 3-5-2 formation and have had success with that. You have to be flexible to adapt, but focus on your own game.
“Our players are looking ready and hungry. They’re enthusiastic to be playing again and we’ll need that at Accrington.”
The only player requiring treatment over Christmas was Lee Brown, but the left-back could be involved at the weekend.
Jackett said: “Lee’s fine now and is back in training. We’re pleased with his progress and I’m expecting him to be in and around the squad for Saturday.”