Pompey moved up to fifth in the League One table with victory at Shrewsbury.
Goals from Marcus Harness and John Marquis saw them lead comfortably at the break, only for Nathanael Ogbeta to pull one back after the restart.
Danny Cowley's men were then reduced to 10 men when Marquis was dismissed for a challenge on Harry Chapman, but held on for a 2-1 win.
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