Clark Robertson makes his first appearance of the season in Pompey’s Carabao Cup second round tie at Newport.
The skipper has recovered from a foot injury and is one of eight changes from the side that beat Bristol Rovers in the league on Saturday.
Josh Griffiths, Connor Ogilvie and Ronan Curtis are the only players to keep their place in the starting line-up.
Zak Swanson and Haji Mnoga enter the defence, while Tottenham loanee Dane Scarlett partners Joe Pigott up front.
There are also starts for Reeco Hackett, Jay Mingi and Tom Lowery in midfield, while academy duo Josh Dockerill and Adam Payce are on the bench.
Pompey: Griffiths; Swanson, Mnoga, Robertson (c), Ogilvie; Hackett, Mingi, Lowery, Curtis; Scarlett, Pigott
Subs: Oluwayemi, Rafferty, Freeman, Raggett, Pack, Dockerill, Payce, Dale, Jacobs