Joe Morrell returns to the Pompey starting line-up for the first fixture of 2022 at Cambridge.
The midfielder replaces Miguel Azeez in the only change from the side that beat Morecambe 23 days ago.
Clark Robertson, Louis Thompson and Ryan Tunnicliffe have all returned to training following injuries, but none are ready to return to the matchday squad.
Blues academy graduate Adam May – who made 30 appearances for the club – is named in the Cambridge midfield.
Pompey: Bazunu; Freeman, Raggett (c), Ogilvie; Romeo, Morrell, Williams, Hackett; Harness; Hirst, Curtis
Subs: Bass, Downing, Brown, Azeez, Jacobs, Harrison, Marquis