Pompey already know they will head the League One table at Christmas, but attention switches to cup progress this evening.
A place in the last 16 of the Bristol Street Motors Trophy – and a home tie with Oxford – lies in wait when AFC Wimbledon visit Fratton Park (7.45pm kick-off).
It will be the third successive campaign that the sides have met in this competition, although the previous two contests were both in the group stage.
The Blues won a bonus point shoot-out following a 1-1 draw on the south coast last season, with Ronan Curtis on target.
John Mousinho’s men reached this stage by topping Group E, while their opponents were runners-up behind Wycombe in Group C.
Like their hosts, the main priority for the Dons this term will be trying to secure promotion and they currently sit seventh in League Two.
A goalless draw at Salford on Saturday meant that they have kept clean sheets in each of their past three games.
Johnnie Jackson’s side also remain in the FA Cup, with thumping wins against Cheltenham and Ramsgate securing a home tie with Ipswich in the new year.
In the event of a draw after 90 minutes, there will be no extra-time and the tie will head straight to penalties.
TEAM NEWS
Pompey are missing Tino Anjorin (hamstring), Josh Dockerill (knee), Connor Ogilvie (ankle) and Regan Poole (knee).
And Sean Raggett is serving a one-match ban after being sent off at Leyton Orient in the final group stage fixture.
Former Blues players Alex Bass – who is on loan from Sunderland – and Lee Brown could feature for the visitors.
VIEW FROM THE DRESSING ROOM
Read the thoughts of John Mousinho and Terry Devlin ahead of the game.
HEAD TO HEAD*
Overall
Pompey: 20 wins
Wimbledon: 15 wins
11 draws
At Fratton Park
Pompey: 13 wins
Wimbledon: 4 wins
6 draws
*Includes matches against Wimbledon FC
TICKETS & TRAVEL
Secure your ticket online here, with seats now available in the Fratton End due to strong sales.
The Anson Road ticket office is also open, while the booth behind the Fratton End will be selling tickets this evening.
Please note that there is a price increase for tickets purchased on the day of the game.
Season ticket holder seats were not reserved for this game. They will need a match ticket and cannot use their season card.
No programme has been produced for this fixture, while the Victory Bar and FanZone are not open tonight, but the shipping container in the Fratton End will be selling refreshments as usual.
If you are driving to the game, please note that the southbound lane of the Eastern Road remains closed due to a burst sewer and is not expected to open again until Wednesday at the earliest.
OFFICIALS
Referee: Craig Hicks
Assistants: Mark Derrien and Andy Bennett
Fourth Official: Farai Hallam
MATCH COVERAGE
Supporters at home and abroad can watch the contest live by purchasing an iFollow match pass and visiting the match centre.
Domestic iFollow subscribers can also enjoy audio commentary from Andrew Moon and Guy Whittingham as usual, but will need to purchase a match pass if they want to watch the game.
Click here for more information about using iFollow on a matchday and click here for information on downloading the app, so you can access content on your mobile device.
We will have key updates throughout the game on Twitter and a detailed blog via the match centre.
There will be post-match reaction on the website and our official YouTube channel, with highlights to follow on Wednesday.
Local listeners can hear commentary by tuning in to either Express FM or BBC Radio Solent (not available online).
EFL TROPHY ROUND OF 16 DRAW
Southern Section
Brighton U21 v Reading
Peterborough v Crawley
Pompey or AFC Wimbledon v Oxford
Wycombe v West Ham U21
Northern Section
Blackpool v Burton
Derby v Bradford
Doncaster v Wigan
Accrington v Bolton
LAST MEETING