Pompey will be looking to ensure it is a day to remember when they make the long trip north to Bolton on Saturday (3pm kick-off).
There are a host of permutations involving results elsewhere that could see them celebrating promotion come 5pm in the event of a draw.
Alternatively, the Blues can make life simple for themselves by winning the game, which would secure the League One title.
But their opponents will be out to stop the party, as they look to boost their own chances of reaching the Championship.
Wanderers are currently sitting in third position and just two points behind Derby, while also holding a game in hand.
Ian Evatt’s men come into the contest on the back of successive victories over Reading and Bristol Rovers.
They will be particularly keen to avoid the lottery of the play-offs, having been beaten over two legs by Barnsley last season.
Goals from Conor Shaughnessy and Kusini Yengi secured a deserved 2-0 victory for Pompey at Fratton Park in a televised contest back in December.
But when the sides met twice on Bolton’s patch in the space of four days last season – just before the arrival of John Mousinho – the hosts came out on top on both occasions.
TEAM NEWS
Tom Lowery is available again following a hamstring problem, although Saturday’s game will come too soon for Callum Lang.
Terry Devlin (shoulder), Josh Dockerill (knee), Tom McIntyre (ankle), Joe Morrell (knee), Regan Poole (knee), Anthony Scully (ankle) and Alex Robertson (hamstring) are all out for the remainder of the season.
Ricardo Santos and Josh Sheehan should both be ready to feature for the visitors after recovering from injury scares, while a fit-again Dion Charles could be on the bench.
VIEW FROM THE DRESSING ROOM
Read the thoughts of John Mousinho and Connor Ogilvie ahead of the game.
HEAD TO HEAD
Overall
Pompey: 38 wins
Bolton: 44 wins
23 draws
On the road
Pompey: 10 wins
Bolton: 34 wins
8 draws
OFFICIALS
Referee: Anthony Backhouse
Assistants: Matthew Smith and Mark Russell
Fourth Official: Scott Simpson
TICKETS
Pompey have sold their full allocation for this game, so please do not travel if you do not already have a ticket.
MATCH COVERAGE
Domestic iFollow subscribers can listen to live commentary from Andrew Moon and Guy Whittingham by signing into their account and visiting the match centre from around 2pm on Saturday.
Overseas subscribers and match pass holders can watch all the action live, with replays and accompanying commentary.
Click here for more information about using iFollow on a matchday and click here for information on downloading the app, so you can access content on your mobile device.
We will have key updates throughout the game on Twitter and a detailed blog via the match centre.
There will be post-match reaction on the website and our official YouTube channel, with highlights to follow on Sunday.
Local listeners can hear commentary by tuning in to either BBC Radio Solent or Express FM (not available online).
ALSO IN LEAGUE ONE
All games kick-off at 3pm
Barnsley v Reading
Cambridge v Charlton
Carlisle v Blackpool
Cheltenham v Bristol Rovers
Derby v Leyton Orient
Fleetwood v Northampton
Lincoln v Wigan
Oxford v Peterborough
Port Vale v Exeter
Shrewsbury v Wycombe
Stevenage v Burton
LAST MEETING
