The old adage is that the Fratton End can suck the ball into the back of the net when the hosts are attacking it during the second half.
So it probably came as no surprise that Cambridge decided to swap ends after winning the toss before kick-off on Tuesday night.
However, the redeveloped Milton End is now able to house plenty of home supporters and they did their bit to aid the side scoring twice after the break to secure a 3-1 victory.
And John Mousinho will be hoping the Fratton faithful can play a similar role when Reading visit this weekend.
The Blues boss said: “It has made a massive difference having our fans behind the goal in the Milton End.
“You saw that when we were spun around by Cambridge, with the thinking that it would benefit them for us not to be shooting towards the Fratton End in the second half.
“But we were actually much more effective after the break and they both feel like home ends for us at the moment.
"It has made a massive difference having our fans behind the goal in the Milton End."
“The support just keeps on building and everyone’s excited about what we’re trying to build this season.
“Now we face a Reading side who are in really good form and have taken themselves away from the relegation zone.
“They’ve been able to bounce back from the points deduction and everything that’s being going on off the pitch.
“Reading have got some very good players in the squad and are well coached, so they’re a definite threat and it should be a competitive contest.”
Tom Lowery limped from the pitch during the first half on Tuesday night after injuring his hamstring, joining fellow midfielders Joe Morrell, Alex Robertson and Terry Devlin on the sidelines.
Mousinho said: “It’s a grade two tear and he’s seeing a specialist on Wednesday, so we’ll have a bit more information after that. I won’t put a timescale on it yet.
“Aside from Owen Moxon, Myles Peart-Harris can play there and Conor Shaughnessy has done before, while a more obvious one for us is Zak Swanson.
“He’s not training with us yet, but I expect him to do so by the end of next week. Ben Stevenson is on schedule, but is not returning imminently.”